Biomarkers

Lost in dichotomization: Preserving statistical power and sensitivity in MS cognitive research.
BACKGROUND: Research on cognitive impairment in multiple sclerosis (MS) often reduces performance across diverse domains-such as …
Jeroen Van Schependom, Gary Cutter
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The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis.
Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of …
Fahimeh Akbarian, Chiara Rossi, Lars Costers, Marie B. D'hooghe, Miguel D'haeseleer, Guy Nagels, Jeroen Van Schependom
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The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis.
Brain age as a surrogate marker for cognitive performance in multiple sclerosis.
BACKGROUND AND PURPOSE: Data from neuro-imaging techniques allow us to estimate a brain’s age. Brain age is easily interpretable …
Stijn Denissen, Denis Alexander Engemann, Alexander De Cock, Lars Costers, Johan Baijot, Jorne Laton, Iris-Katharina Penner, Matthias Grothe, Michael Kirsch, Marie Beatrice D'hooghe, Miguel D'haeseleer, Dominique Dive, Johan De Mey, Jeroen Van Schependom, Diana Maria Sima, Guy Nagels
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Plasma glial fibrillary acidic protein and neurofilament light chain in relation to disability worsening in multiple sclerosis.
BACKGROUND: Predicting disability worsening in multiple sclerosis (MS) remains an important challenge. Glial fibrillary acidic protein …
Ayla Pauwels, Jeroen Van Schependom, Lindsay Devolder, Ann Van Remoortel, Guy Nagels, Maria Bjerke, Marie B. D'hooghe
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Improved Alzheimer's Disease versus Frontotemporal Lobar Degeneration Differential Diagnosis Combining EEG and Neurochemical Biomarkers: A Pilot Study.
BACKGROUND: Distinguishing between Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) results in poor …
Jorne Laton, Jeroen Van Schependom, Joery Goossens, Wietse Wiels, Anne Sieben, Peter Paul De Deyn, Johan Goeman, Johannes Streffer, Julie van der Zee, Jean-Jacques Martin, Christine Van Broeckhoven, Maarten De Vos, Maria Bjerke, Guy Nagels, Sebastiaan Engelborghs
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Callosal circularity as an early marker for Alzheimer's disease.
BACKGROUND: Although brain atrophy is considered to be a downstream marker of Alzheimer’s disease (AD), subtle changes may allow …
Jeroen Van Schependom, Ellis Niemantsverdriet, Dirk Smeets, Sebastiaan Engelborghs
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Callosal circularity as an early marker for Alzheimer's disease.
EEG Dominant Frequency Peak Differentiates Between Alzheimer's Disease and Frontotemporal Lobar Degeneration.
We investigated the power of EEG as biomarker in differential diagnosis of Alzheimer’s disease (AD) and frontotemporal lobar …
Joery Goossens, Jorne Laton, Jeroen Van Schependom, Jeroen Gielen, Hanne Struyfs, Sara Van Mossevelde, Tobi Van den Bossche, Johan Goeman, Peter Paul De Deyn, Anne Sieben, Jean-Jacques Martin, Christine Van Broeckhoven, Julie van der Zee, Sebastiaan Engelborghs, Guy Nagels
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Reliability of measuring regional callosal atrophy in neurodegenerative diseases.
The Corpus Callosum (CC) is an important structure connecting the two brain hemispheres. As several neurodegenerative diseases are …
Jeroen Van Schependom, Saurabh Jain, Melissa Cambron, Anne-Marie Vanbinst, Johan De Mey, Dirk Smeets, Guy Nagels
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